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Home > Grand Challenge Seed Program > On-going Programs　　（Past Programs）

Division of Mathematics and Physical Sciences

Project No.	Project Title	Project Principal Investigator	Affiliation	Execution Period
AS-GCS-113-M01	Unraveling the Complexity of Three-Dimensional Spatial Biology Through the Integration of Advanced Technologies	Peilin Chen	Research Center for Applied Sciences, Academia Sinica	2024-01-01 ~ 2025-12-31
AS-GCS-113-M02	Modulating macrophage polarization with H2-evolving systems for treating inflammatory diseases	Yu-Jung Lin	Research Center for Applied Sciences, Academia Sinica	2024-01-01 ~ 2025-12-31
AS-GCS-113-M03	Dynamic Chromatin Structures in Gene Expression Resolved by Advanced Microscopy	Chia-Lung Hsieh	Institute of Atomic and Molecular Sciences, Academia Sinica	2024-01-01 ~ 2025-12-31
AS-GCS-113-M04	Deciphering the Origins of Ultra-High Energy Cosmic Rays: Mitigating Magnetic Field Effects with Deep Learning	Anatoli Fedynitch	Institute of Physics, Academia Sinica	2024-01-01 ~ 2025-12-31
AS-GCS-113-M05	Identifying Holes of Arbitrary Dimensions and Quantifying their Distributions in Large-Scale Networks	Chen-Hsiang Yeang	Institute of Statistical Science	2024-01-01 ~ 2025-12-31
AS-GCS-113-M06	New Perspectives in Quantum Complexity and Automata Theory	Kai-Min Chung	Institute of Information Science	2024-01-01 ~ 2025-12-31
AS-GCS-113-M07	Efficient, Secure, Formally Verified Correct Postquantum Crypto Libraries	Bo-Yin Yang	Institute of Information Science	2024-01-01 ~ 2025-12-31
AS-GCS-112-M01	Unveil the mystery of breath: how facilitated oxygen transport occurs in the alveolus	Chin-Lin Guo	Institute of Physics	2023-01-01 ~ 2024-12-31
AS-GCS-112-M02	Cellular logic gate and cellular memory device	Ji-Yen Cheng	Research Center for Applied Sciences	2023-01-01 ~ 2024-12-31
AS-GCS-112-M03	Recovering missing cryo-EM densities of mobile parts in biological machines	Wei-Hau Chang	Institute of Chemistry	2023-01-01 ~ 2024-12-31
AS-GCS-112-M04	Magnetomechanical energy transfer at the nanoscale utilizing two dimensional magnetic resonators	Ya-Ping Hsieh	Institute of Atomic and Molecular Sciences	2023-01-01 ~ 2024-12-31
AS-GCS-112-M05	ncluding non equilibrium kinetics in pMHC-TCR interactions to improve in silico screening power and Spectrum for vaccine design and development	Chin-Lin Guo	Institute of Physics	2023-07-01 ~ 2025-06-30
AS-GCS-112-M06	Intelligent Q&A Agent Based on Large Language Models	Lun-Wei Ku	Institute of Information Science	2023-07-01 ~ 2025-06-30
AS-GCS-111-M03	The coupling of coastal blue carbon and the newly emerging seaweed economy	Yi-Chia Hsin	Research Center for Environmental Changes	2022-06-01 ~ 2024-05-31
AS-GCS-111-M04	Impact of climate oscillations on East Asian macro weather patterns－monsoon decadal dynamics and predictability	Chi-Hua Wu	Research Center for Environmental Changes	2022-06-01 ~ 2024-05-31

Division of Life Sciences

Project No.	Project Title	Project Principal Investigator	Affiliation	Execution Period
AS-GCS-113-L01	Unraveling the Mystery of TRAX: A Novel Mechanism for Sorting miRNAs into Extracellular Vesicles in Huntington's Disease	Yijuang Chern	Institute of Biomedical Sciences, Academia Sinica	2024-01-01 ~ 2025-12-31
AS-GCS-113-L02	To study how microbial glycoconjugates are dynamically modified to orchestrate the host immune response	Chun-Hung Lin	Institute of Biological Chemistry, Academia Sinica	2024-01-01 ~ 2025-12-31
AS-GCS-113-L03	Mechanism of Ultrashort Intron Splicing with Reduced Spliceosomes	Chien-Ling Lin	Institute of Molecular Biology	2024-01-01 ~ 2025-12-31
AS-GCS-113-L04	Establish a high-throughput platform to generate, customize and validate CAR-NK cells	Kuen-Phon Wu	Institute of Biological Chemistry	2024-01-01 ~ 2025-12-31
AS-GCS-113-L05	Advancing Ubiquitin Biological Pathways through Deep Learning-Guided Protein Design	Kuen-Phon Wu	Institute of Biological Chemistry	2024-01-01 ~ 2025-12-31
AS-GCS-113-L06	Deciphering partial altitudinal migration in the Asian House Martin (Delichon dasypus): from genomics to physiology	Chih-Ming Hung	Biodiversity Research Center	2024-01-01 ~ 2025-12-31
AS-GCS-113-L07	Unveiling Root Nitrate Dynamics: Pioneering Precision for Sustainable Crop Enhancement	Cheng-Hsun Ho	Agricultural Biotechnology Research Center	2024-01-01 ~ 2025-12-31
AS-GCS-112-L01	Molecular and cellular dissection of asynthetic fission in zebrafish	Chen-Hui Chen	Institute of Cellular and Organismic Biology	2023-01-01 ~ 2024-12-31
AS-GCS-112-L02	Precise control of neuronal RNA splicing in the critical developmental window to counteract stress sensitization	Pei-Lin Cheng	Institute of Molecular Biologyy	2023-01-01 ~ 2025-12-31
AS-GCS-112-L03	PHR1/PHL1‐Mediated Long‐Distance Signaling in Regulating Phosphate Starvation Responses in the Roots	Tzyy‐Jen Chiou	Agricultural BiotechnologyResearch Cente	2023-01-01 ~ 2024-12-31
AS-GCS-111-L04	Design Cancer therapy via propagating cell death waves	Sheng-hong Chen	Institute of Molecular Biology	2022-06-01 ~ 2024-05-31
AS-GCS-111-L05	Development of broad-spectrum COVID-19 vaccine	Che Alex Ma	Genomics Research Center	2022-06-01 ~ 2024-05-31
AS-GCS-111-L06	Biosynthesis and impact on plant development of a promising new plant growth regulator, stigmin	Guang-Yuh Jauh	Institute of Plant and Microbial Biology	2022-06-01 ~ 2024-05-31

Division of Humanities and Social Sciences

Project No.	Project Title	Project Principal Investigator	Affiliation	Execution Period
AS-GCS-113-H01	The Great Social Transformation in Southern Taiwan: Community-based Social, Economic, Cultural and Medical Care Integrated Research	CHYI-IN WU, Zong-Rong Lee, Wei-Hsian Chi, Yi-Ting Chung, Hui-Ju Kuo, Chung-Ying Lin, Yun-Hsuan Chang	Research Fellow, Associate Research Fellow, Assistant Professor	2024-01-01 ~ 2025-12-31
AS-GCS-113-H02	Jiao Merchants and Commodity Frontiers in East Asia: Networks of People, Knowledge and Materials in the Late Nineteenth and Early Twentieth Century.	Yu-Ju Lin	Institute of Taiwan History	2024-01-01 ~ 2024-12-31
AS-GCS-113-H03	Media coverage of elite cues in policy persuasion	Greg Chih-Hsin Sheen	Institute of Political Science	2024-01-01 ~ 2025-12-31
AS-GCS-113-H04	Governing Generative AI for a Future Society	Chih-hsing Ho	Institute of European and American Studies	2024-01-01 ~ 2025-12-31
AS-GCS-113-H05	Reading and Scholarly Writing: Transformations in the Age of Developing Digital Technologies	Ku-ming (Kevin) Chang	Institute of History and Philology	2024-01-01 ~ 2025-12-31
AS-GCS-112-H01	The Qing Empire’s Reconstruction of Historical Memory and Ethnic Identitiesof Koxinga Taiwan: Research on the Manchu and Chinese Texts of TheCampaign History of Conquering Taiwan Collected by the Institute of History and Philology at Academia Sinica	Ling-Wei Kung	Institute of History and Philology	2023-01-01 ~ 2024-12-31
AS-GCS-112-H02	Online Social and Political Climates and Trust: A Method Triangulation Approach	Ching-Ching Chang	Research Center for Humanities and Social Sciences	2023-01-01 ~ 2024-12-31