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Home > Grand Challenge Seed Program > Past Programs　　（On-going Programs）

Division of Mathematics and Physical Sciences

Project No.	Project Title	Project Principal Investigator	Affiliation	Execution Period
AS-GCS-112-M01	Unveil the mystery of breath: how facilitated oxygen transport occurs in the alveolus	Chin-Lin Guo	Institute of Physics	2023-01-01 ~ 2024-12-31
AS-GCS-112-M02	Cellular logic gate and cellular memory device	Ji-Yen Cheng	Research Center for Applied Sciences	2023-01-01 ~ 2024-12-31
AS-GCS-112-M03	Recovering missing cryo-EM densities of mobile parts in biological machines	Wei-Hau Chang	Institute of Chemistry	2023-01-01 ~ 2024-12-31
AS-GCS-112-M04	Magnetomechanical energy transfer at the nanoscale utilizing two dimensional magnetic resonators	Ya-Ping Hsieh	Institute of Atomic and Molecular Sciences	2023-01-01 ~ 2024-12-31
AS-GCS-111-M03	The coupling of coastal blue carbon and the newly emerging seaweed economy	Yi-Chia Hsin	Research Center for Environmental Changes	2022-06-01 ~ 2024-05-31
AS-GCS-111-M04	Impact of climate oscillations on East Asian macro weather patterns－monsoon decadal dynamics and predictability	Chi-Hua Wu	Research Center for Environmental Changes	2022-06-01 ~ 2024-05-31
AS-GCS-111-M01	Nonlinear light-matter interaction of Weyl semimetals	Yu-Chieh Wen	Institute of Physics	2022-01-01 ~ 2023-12-31
AS-GCS-111-M02	Investigation of how the complex interplay between pectin chemical composition and characteristics, endogenous enzymes and ions affect aiyu gelation physical and rheological properties	Yeng-Long Chen	Institute of Physics	2022-06-01 ~ 2024-05-31
AS-GCS-111-M05	Condensing deep learning models for efficient prediction acceleration through layer-wise low-rank approximation	Ching-pei Lee	Institute of Statistical Science	2022-06-01 ~ 2023-03-31
AS-GCS-110-07	Development of iterative π-extension reaction toward precise synthesis of heteroatom-doped nanographene	Hsiao-hua Yu	Institute of Chemistry	2021-07-01 ~ 2023-06-30
AS-GCS-110-08	Alchemizing Skyrmion Racetrack Memory for Ultra-high Performance Computing in the Future	Yuan-Hao Chang	Institute of Information Science	2021-07-01 ~ 2023-06-30
AS-GCS-109-07	Virus Hunter: Smart Genotyping on Upper Respiratory Pathogens	Chung-Yen Lin	Institute of Information Science	2020-07-01 ~ 2021-12-31
AS-GCS-109-08	An optoelectromechanical approach towards optical quantum communication for cQED superconducting qubits	Chii-Dong Chen	Institute of Physics	2020-07-01 ~ 2021-12-31
AS-GCS-109-10	Immune cell classification by deep learning-based feature extraction and pattern recognition	Jung-Chi Liao	Institute of Atomic and Molecular Sciences	2020-07-01 ~ 2022-06-30
AS-GCS-109-12	Observatory of the Exchange-Correlation Hole in Quantum Materials	Cheng-Tien Chiang	Institute of Atomic and Molecular Sciences	2020-07-01 ~ 2022-06-30
AS-GCS-109-05	Development of advanced speech signal processing algorithms for assistive hearing devices	Yu Tsao	Research Center for Information Technology Innovation	2020-01-01 ~ 2021-12-31
AS-GCS-109-06	Applications of logically derived sequence tandem mass spectrometry on the structural determination of N-glycans	Chi-Kung Ni	Institute of Atomic and Molecular Sciences	2020-01-01 ~ 2021-12-31
AS-GCS-108-13	High resolution, long working distance, large field of view optical objectives	Bi‐Chang Chen	Research Center for Applied Sciences	2019-07-01 ~ 2021-06-30
AS-GCS-108-01	Intent Transition Identification in Cross-domain Services	Chih-Yu Wang	Research Center for Information Technology Innovation	2019-01-01 ~ 2019-12-31
AS-GCS-108-02	Precision diagnosis and treatment of autism spectrum disorders by using an integrative study of human genome and brain image data	Hsin-Chou Yang	Institute of Statistical Science	2019-01-01 ~ 2020-12-31
AS-GCS-108-03	Plant uptake and the associated carbon cycling fluxes from terrarium experiments	Mao-Chang Liang	Institute of Earth Sciences	2019-01-01 ~ 2020-12-31
AS-GCS-108-08	ASCEP: a speedy and robust cryo-EM processing platform	I-Ping Tu	Institute of Statistical Science	2019-01-01 ~ 2020-12-31

Division of Life Sciences

Project No.	Project Title	Project Principal Investigator	Affiliation	Execution Period
AS-GCS-112-L01	Molecular and cellular dissection of asynthetic fission in zebrafish	Chen-Hui Chen	Institute of Cellular and Organismic Biology	2023-01-01 ~ 2024-12-31
AS-GCS-112-L03	PHR1/PHL1‐Mediated Long‐Distance Signaling in Regulating Phosphate Starvation Responses in the Roots	Tzyy‐Jen Chiou	Agricultural BiotechnologyResearch Cente	2023-01-01 ~ 2024-12-31
AS-GCS-111-L04	Design Cancer therapy via propagating cell death waves	Sheng-hong Chen	Institute of Molecular Biology	2022-06-01 ~ 2024-05-31
AS-GCS-111-L05	Development of broad-spectrum COVID-19 vaccine	Che Alex Ma	Genomics Research Center	2022-06-01 ~ 2024-05-31
AS-GCS-111-L06	Biosynthesis and impact on plant development of a promising new plant growth regulator, stigmin	Guang-Yuh Jauh	Institute of Plant and Microbial Biology	2022-06-01 ~ 2024-05-31
AS-GCS-111-L01	Deciphering the effects of circadian disruption and the functions of core clock gene BMAL1 and BMAL2 in epithelial ovarian cancer	Wendy W. Hwang-Verslues	Genomics Research Center	2022-01-01 ~ 2023-12-31
AS-GCS-111-L02	Principles underlying precise organelle abundance control	Wei-Yuan Yang	Institute of Biological Chemistry	2022-01-01 ~ 2023-12-31
AS-GCS-110-03	Structural analysis of the transcription-splicing supra-machinery	Tien-Hsien Chang	Genomics Research Center	2021-07-01 ~ 2023-06-30
AS-GCS-110-04	Regulation of the gut-brain axis: to investigate how lysosome dysfunction in the gut contributes to Parkinson’s disease	Jr-Wen Shui	Institute of Biomedical Sciences	2021-07-01 ~ 2023-06-30
AS-GCS-110-05	Investigation of inter-species mRNA exchange between plants and fungi	Tien-Shin Yu	Institute of Plant and Microbial Biology	2021-07-01 ~ 2023-06-30
AS-GCS-110-06	The development of ultra-high-resolution expansion microscopy (E x MM) to break barriers of nanoscale observation in plants	Chung-Ju Rachel Wang	Institute of Plant and Microbial Biology	2021-07-01 ~ 2023-06-30
AS-GCS-110-01	Co-evolution of extrachromosomal circular DNA and transcriptional condensates	Cheng-Fu Kao	Institute of Cellular and Organismic Biology	2021-01-01 ~ 2022-12-31
AS-GCS-110-02	Advanced Instrumentation and Technology Research Program	Yi-Sheng Wang	Genomics Research Center	2021-01-01 ~ 2022-03-31
AS-GCS-109-09	Development of a synthetic counter to record life events for nematodes	John Wang	Biodiversity Research Center	2020-07-01 ~ 2021-06-30
AS-GCS-109-01	Development of an Engineered Autocrine Receptor (EAR) system functioning as auto-regulatory circuit for CAR T therapy potency	Jeffrey J.Y. Yen	Institute of Biological Chemistry	2020-01-01 ~ 2021-12-31
AS-GCS-109-02	Unraveling the impact of exogenous DNA-induced nucleosome rearrangement and damages during CRISPR	Steven Lin	Institute of Biological Chemistry	2020-01-01 ~ 2020-12-31
AS-GCS-109-03	Exploring and testing the application of microRNAs to counteract the aging process in vivo	Jun-An Chen	Institute of Molecular Biology	2020-01-01 ~ 2021-12-31
AS-GCS-109-04	Fab/antigen complex structure determination by cryoEM	Meng-Chiao Ho	Institute of Biological Chemistry	2020-01-01 ~ 2020-12-31
AS-GCS-108-09	The stochastic storm in the brain	Ya-Hui Chou	Institute of Cellular and Organismic Biology	2019-07-01 ~ 2021-06-30
AS-GCS-108-05	Outmaneuver the glycosylation mediated immunosuppression and tumor aggression to prime cell therapy	Tzu-Ching Meng	Institute of Biological Chemistry	2019-01-01 ~ 2020-12-31
AS-GCS-108-06	Deep Learning for Detection of Circulating Tumor Cells (Deep-CTC) in Fluorescence Microscopy Images	Ying-Chih Chang	Genomics Research Center	2019-01-01 ~ 2020-12-31
AS-GCS-108-07	Elucidating Pathogenic Mechanism of Tau Spreading in Alzheimer’s Disease	Yun-Ru Chen	Genomics Research Center	2019-01-01 ~ 2020-12-31
AS-GCS-107-01	A safe journey to the ovule: rapid and practical transformation of maize	Chung-Ju Rachel Wang	Institute of Plant and Microbial Biology	2018-07-01 ~ 2019-06-30
AS-GCS-107-02	Treatment of chronic pain by targeting PVA in aged animals	Chien-Chang Chen	Institute of Biomedical Sciences	2018-07-01 ~ 2019-06-30

Division of Humanities and Social Sciences

Project No.	Project Title	Project Principal Investigator	Affiliation	Execution Period
AS-GCS-113-H02	Jiao Merchants and Commodity Frontiers in East Asia: Networks of People, Knowledge and Materials in the Late Nineteenth and Early Twentieth Century.	Yu-Ju Lin	Institute of Taiwan History	2024-01-01 ~ 2024-12-31
AS-GCS-112-H01	The Qing Empire’s Reconstruction of Historical Memory and Ethnic Identitiesof Koxinga Taiwan: Research on the Manchu and Chinese Texts of TheCampaign History of Conquering Taiwan Collected by the Institute of History and Philology at Academia Sinica	Ling-Wei Kung	Institute of History and Philology	2023-01-01 ~ 2024-12-31
AS-GCS-112-H02	Online Social and Political Climates and Trust: A Method Triangulation Approach	Ching-Ching Chang	Research Center for Humanities and Social Sciences	2023-01-01 ~ 2024-12-31
AS-GCS-108-10	Civic philosophy: normativity and causality	Norman Y. Teng	Institute of European and American Studies	2019-07-01 ~ 2021-06-30
AS-GCS-108-11	Time and Space in Oracle Bone Inscriptions (Part II)	Ming-chorng Hwang	Institute of History and Philology	2019-07-01 ~ 2021-06-30
AS-GCS-108-12	Disclosing and Disrupting the Dark Networks: Part II	Yen-sheng Chiang	Institute of Sociology	2019-07-01 ~ 2021-06-30
AS-GCS-108-04	To improve the detection of mild cognitive impairment and Alzheimer’s disease by simultaneous recording of eye-movement and electrical brain potentials in natural reading	Chia-Ying Lee	Institute of Linguistics	2019-01-01 ~ 2020-12-31
AS-GCS-107-03	Civic philosophy	Norman Y. Teng	Institute of European and American Studies	2018-07-01 ~ 2019-06-30