中文 Home > Grand Challenge Program > On-going Programs　　（Past Programs）   Division of Mathematics and Physical Sciences Project No. Project Title Project Principal Investigator Affiliation Execution Period AS-GC-110-01 Diagnosis and Attribution of Air Pollution in Central-Western Taiwan Charles C.-K. Chou Research Center for Environmental Changes 2021-01-01 ~ 2024-12-31 AS-GC-110-02 Quantum Photonics “CW” Project: from Fundamental Breakthroughs to Enabling Devices Wen-Hao Chang Research Center for Applied Sciences 2021-01-01 ~ 2024-12-31 AS-GC-110-03 Earthquake and tsunami hazard assessment along the Taiwan plate boundary zone using seafloor geodesy Ya-Ju Hsu Institute of Earth Sciences 2021-01-01 ~ 2024-12-31 AS-GC-110-MD06 Revealing Environmental Carcinogens Induced Tumorigenesis and Developing Curative Treatments for Never-Smoking Lung Adenocarcinoma in Taiwan Hsuan-Yu Chen Institute of Statistical Science 2021-01-01 ~ 2024-12-31 AS-GC-111-M01 Ubiquitous Assistive Oral Communication Technologies Yu Tsao Research Center for Information Technology Innovation 2022-01-01 ~ 2025-12-31 AS-GC-111-M02 A synthetic protein-enabled digital chemical recognition system Pei-Kuen Wei Research Center for Applied Sciences 2022-01-01 ~ 2024-12-31 AS-GC-111-M03 Decode and Modulate the Sweet Tumor Microenvironment by Micro-to-single Cell Multi-proteomics Station and Targeting Materials Yu-Ju Chen Institute of Chemistry 2022-01-01 ~ 2025-12-31 AS-GC-111-M04 Reinvigorating Carbon and Main Group Features with Non-Octet Strategy for Sustainable Catalysis Tiow-Gan Ong Institute of Chemistry 2022-01-01 ~ 2024-12-31 AS-GC-111-M05 Functionalization and Assembly of Molecular Nanocarbons for Bioengineering Hsiao-hua Yu Institute of Chemistry 2022-01-01 ~ 2024-12-31 AS-GCP-112-M01 Innovating cQED Architecture for High-Performance Qubits ChiiDong Chen Institute of Physics 2023-01-01 ~ 2026-12-31 AS-GCP-112-M02 Harnessing the energy of the Kuroshio Current Chau-Ron Wu Research Center for Environmental Changes 2023-01-01 ~ 2026-12-31 AS-GCP-112-M03 Development of digital twin for climate change Huang-Hsiung Hsu Research Center for Environmental Changes 2023-01-01 ~ 2024-12-31 Division of Life Sciences Project No. Project Title Project Principal Investigator Affiliation Execution Period AS-GC-110-04 Glycoscience on the Inside: Unravelling the Role of Intracellular Glycans and Glycan Binding Proteins Todd Lowary Institute of Biological Chemistry 2021-01-01 ~ 2024-12-31 AS-GC-110-05 Investigate the immunosurveillance network in response to oxidative stress associated diseases using multiplexed single‐cell technologies and its translational application multiplexed single‐cell technologies and its translational application Shih-Yu Chen Institute of Biomedical Sciences 2021-01-01 ~ 2024-12-31 AS-GC-110-06 From the ground up – deciphering the pathogen, host, and disease suppressive soil interactions involved in Fusarium wilt of banana Yu-Liang Yang Agricultural Biotechnology Research Center 2021-01-01 ~ 2024-12-31 AS-GC-110-MD01 Application of GRC2 recombinant protein to induce ‘regenerative macrophage’ (MfTR) for tissue repairing and prevention of fibrosis Shie-Liang Hsieh Genomics Research Center 2021-01-01 ~ 2024-12-31 AS-GC-110-MD03 Targeting the proximal mechanistic key step of Interleukin-17 receptor B oncogenic signaling for treating pancreatic cancer Chun-Mei Hu Genomics Research Center 2021-01-01 ~ 2024-12-31 AS-GC-110-MD04 Deciphering the molecular basis and functional roles of glycan-based immune checkpoints in neurodegenerative diseases Takashi Angata Institute of Biological Chemistry 2021-01-01 ~ 2024-12-31 AS-GC-111-L01 Towards an integrated understanding of metamorphosis in bilaterians Jr-Kai Yu Institute of Cellular and Organismic Biology 2022-01-01 ~ 2025-12-31 AS-GC-111-L02 Knowledge-based development of an integration-free genome editing platform based on Agrobacterium-mediated transformation by floral inoculation Erh-Min Lai Institute of Plant and Microbial Biology 2022-01-01 ~ 2025-12-31 AS-GC-111-L03 Mechanistic Studies to Elucidate Tau Transmission in Alzheimer's Disease Yun-Ru Chen Genomics Research Center 2022-01-01 ~ 2025-12-31 AS-GC-111-L04 Investigation of the pathogenic mechanism of CADASIL and potential therapeutic interventions Yi-Shuian Huang Institute of Biomedical Sciences 2022-01-01 ~ 2025-12-31 AS-GCP-112-L01 The stochastic storm in the brain Ya-Hui Chou Institute of Cellular and Organismic Biology 2023-01-01 ~ 2026-12-31 AS-GCP-112-L02 Unlocking the mystery of coral spawning synchronization molecular mechanisms: implications for the effect of light pollution on coral sustainability Kwok Kan Chan Biodiversity Research Center 2023-01-01 ~ 2026-12-31 AS-GCP-113-L01 Mechanistic investigation of selectivity interplay between GPCRs and G proteins by structural mass spectrometry HSIN-YUNG YEN Institute of Biological Chemistry, Academia Sinica 2024-01-01 ~ 2027-12-31 AS-GCP-113-L02 Aging hallmarks undergo bistable switches in molecular and cellular processes that lead to cellular and organismal aging Hwai-Jong Cheng, Jun-An Chen, Liuh-Yow Chen, Sheng-hong Chen Institute of Molecular Biology, Academia Sinica 2024-01-01 ~ 2027-12-31 AS-GCP-113-L03 Advancing cancer neoantigen prediction model through immunodominance-agnostic immunogenicity dataset and unbiased expansion of functional T cells Che-Ming Jack Hu, Tai-Ming Ko, Shu-Wha Lin, Tzu-Chun Chen Institute of Biomedical Sciences, Academia Sinica, National Taiwan University, National Taiwan University Cancer Center 2024-01-01 ~ 2027-12-31 Division of Humanities and Social Sciences Project No. Project Title Project Principal Investigator Affiliation Execution Period AS-GC-111-H01 Constructing Social Surveys under the Totalitarian Regime in Contemporary China Chih-Jou Jay Chen Institute of Sociology 2022-01-01 ~ 2025-12-31