中文 Home > Grand Challenge Program > On-going Programs　　（Past Programs）   Division of Mathematics and Physical Sciences Project No. Project Title Project Principal Investigator Affiliation Execution Period AS-GCP-115-M01 Critical devices for advanced photonic quantum technology: Highly efficient quantum light sources and single-photon detectors at telecom bands Wang, Ming-Jye Institute of Astronomy and Astrophysics, Academia Sinica / Research Center for Critical Issues, Academia Sinica / Institute of Astronomy and Astrophysics, Academia Sinica 2026/01/01 ~ 2028/12/31 AS-GCP-115-M02 Decoding Sex-Specific and Environmental Carcinogen-driven Oncogenesis in Non- Smoking Lung Cancer by Multi-omics and Translational Precision Strategies CHEN, YU-JU Institute of Chemistry, Academia Sinica / Institute of Biological Chemistry, Academia Sinica / Institute of Biomedical Sciences, Academia Sinica / Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University 2026/01/01 ~ 2028/12/31 AS-GCP-115-M03 Responsive Fluorescence Lifetime Probes for Multiplexed In Vivo Imaging YU, HSIAO-HUA Institute of Chemistry, Academia Sinica 2026/01/01 ~ 2028/12/31 AS-GCP-115-M04 Automated Intelligence-Empowered Biology Lab – Paving the Way for Human-Centric in vitro Model-Based Drug Exploration TUNG, YI-CHUNG Research Center for Applied Sciences, Academia Sinica 2026/01/01 ~ 2028/12/31 AS-GCP-112-M01 Innovating cQED Architecture for High-Performance Qubits ChiiDong Chen Institute of Physics 2023/01/01 ~ 2026/12/31 AS-GCP-112-M02 Harnessing the energy of the Kuroshio Current Chau-Ron Wu Research Center for Environmental Changes 2023/01/01 ~ 2026/12/31 AS-GC-111-M01 Ubiquitous Assistive Oral Communication Technologies Yu Tsao Research Center for Information Technology Innovation 2022/01/01 ~ 2026/12/31 AS-GC-111-M02 A synthetic protein-enabled digital chemical recognition system Pei-Kuen Wei Research Center for Applied Sciences 2022/01/01 ~ 2026/12/31 AS-GC-111-M03 Decode and Modulate the Sweet Tumor Microenvironment by Micro-to-single Cell Multi-proteomics Station and Targeting Materials Yu-Ju Chen Institute of Chemistry 2022/01/01 ~ 2026/12/31 Division of Life Sciences Project No. Project Title Project Principal Investigator Affiliation Execution Period AS-GCP-115-L01 Cracking and leveraging protein destruction codes to transform biology and medicine Yen, Hsueh-Chi Institute of Molecular Biology,Academia Sinica / Institute of Statistical Science, Academia Sinica / University of Washington 2026/01/01 ~ 2029/12/31 AS-GCP-115-L02 Investigating how lipopolysaccharides are dynamically modified to orchestrate intra- and extracellular signaling pathways LIN, CHUN-HUNG Institute of Biological Chemistry, Academia Sinica / Institute of Basic Medical Sciences, National Cheng Kung University 2026/01/01 ~ 2029/12/31 AS-GCP-115-L03 Investigating adenosine-mediated metabolic signaling on epitranscriptomic reprograming in Alzheimer’s Disease CHERN, YIJUANG Institute of Biomedical Sciences, Academia Sinica / Institute of Biological Chemistry, Academia Sinica / Institute of Cellular and Organismic Biology, Academia Sinica 2026/01/01 ~ 2029/12/31 AS-GCP-113-L01 Mechanistic investigation of selectivity interplay between GPCRs and G proteins by structural mass spectrometry HSIN-YUNG YEN Institute of Biological Chemistry, Academia Sinica 2024/01/01 ~ 2027/12/31 AS-GCP-113-L02 Aging hallmarks undergo bistable switches in molecular and cellular processes that lead to cellular and organismal aging Hwai-Jong Cheng, Jun-An Chen, Liuh-Yow Chen, Sheng-hong Chen Institute of Molecular Biology, Academia Sinica 2024/01/01 ~ 2027/12/31 AS-GCP-113-L03 Advancing cancer neoantigen prediction model through immunodominance-agnostic immunogenicity dataset and unbiased expansion of functional T cells Che-Ming Jack Hu, Tai-Ming Ko, Shu-Wha Lin, Tzu-Chun Chen Institute of Biomedical Sciences, Academia Sinica, National Taiwan University, National Taiwan University Cancer Center 2024/01/01 ~ 2027/12/31 AS-GCP-112-L01 The stochastic storm in the brain Ya-Hui Chou Institute of Cellular and Organismic Biology 2023/01/01 ~ 2026/12/31 AS-GCP-112-L02 Unlocking the mystery of coral spawning synchronization molecular mechanisms: implications for the effect of light pollution on coral sustainability Kwok Kan Chan Biodiversity Research Center 2023/01/01 ~ 2026/12/31 AS-GC-111-L01 Towards an integrated understanding of metamorphosis in bilaterians Jr-Kai Yu Institute of Cellular and Organismic Biology 2022/01/01 ~ 2026/12/31 AS-GC-111-L02 Knowledge-based development of an integration-free genome editing platform based on Agrobacterium-mediated transformation by floral inoculation Erh-Min Lai Institute of Plant and Microbial Biology 2022/01/01 ~ 2026/12/31 AS-GC-111-L03 Mechanistic Studies to Elucidate Tau Transmission in Alzheimer's Disease Yun-Ru Chen Genomics Research Center 2022/01/01 ~ 2026/12/31 AS-GC-111-L04 Investigation of the pathogenic mechanism of CADASIL and potential therapeutic interventions Yi-Shuian Huang Institute of Biomedical Sciences 2022/01/01 ~ 2026/12/31 Division of Humanities and Social Sciences Project No. Project Title Project Principal Investigator Affiliation Execution Period AS-GCP-115-H01 Creativity in the Age of Artificial Intelligence Chang, Ku-ming (Kevin) Institute of History and Philology, Academia Sinica / Institute of Information Science, Academia Sinica / Institutum Iurisprudentiae, Academia Sinica 2026/01/01 ~ 2028/12/31 AS-GC-111-H01 Constructing Social Surveys under the Totalitarian Regime in Contemporary China Chih-Jou Jay Chen Institute of Sociology 2022/01/01 ~ 2026/12/31